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KMID : 0354719760030010001
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Journal of Korean Diabetes Association
1976 Volume.3 No. 1 p.1 ~ p.5
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Continuous Low-dose Insulin Infusion VS. Conventional Intermittent Injections in the Treatment of Serve Hyperglycemia
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李惠利/Lee, Hye Ree
韓旻熙/尹珍雨/韓德鎬/許甲範/李相龍/Min Hie Han/Yoon/Yoon, Jhin Woo/Han, Duck Ho/Huh, Kap Bum
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Abstract
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A new and simple form of insulin therapy using a continuous low-dose intravenous infusion of insulin was evaluated in the treatment of diabetic hyperglycemia and ketoacidosis.
It was employed as a standard protocol that a priming intravenous injection of 4U. of regular insulin was followed by continuous infusion of 25U. of regular insulin mixed with 500cc of 0.9% normal saline.
Ten cases of severe diabetes mellitus treated with the conventional multiple subcutaneous injections of insulin were compared with 20 episodes of similar severity in 18 cases treated with continuous insulin infusion.
The results are as follows;
1. The mean plasma glucose at the time of admission was 457.7 mg% (310^848 mg%) in control group and 438.2 mg% (320^541 mg´/´o) in experimental group.
2. ´The total amount of insulin required for glucose to reach 200 mgo in experimental group (35.5019.98 U) was significantly smaller than that of control group(164.599.69 U.) (p<0.01)
3. The time taken for glucose to reach 200 mg% in experimental group (10.466.13 hours} was shorter than that of control group (19.0515.71 hours) (p<0.05)
4. Hypoglycemia (glucose<50 mg%) was noted in 2 of 10 cases (20961) and hypokalemia (K <3.0 mEq/L) in 2 of 8 cases (25%) in control group. In contrast hypoglycemia was not noted and hypokalemia in 1 of 8 cases (12.5%) in experimental group.
Continuous low-dose insulin infusion is simple, safe, effective and appears to be the method of choice in the treatment of diabetic hyperglycemia and ketoacidosis.
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